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by José Machado · Lengua de Trapo · tapa blanda · ISBN 9788496080195
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ISBN: 9788496080195
Grillo es una novela del escritor español José Machado, publicada en 2003. La historia sigue a un autor sin éxito que intenta recuperar el control de su vida con la ayuda de una joven vecina y su mejor amigo, después de que su novia lo dejara y aún no haya superado la muerte de sus padres y su abuelo. Ambientada en Madrid, la novela explora temas de pérdida, amistad y la búsqueda de sentido en la vida cotidiana.
Machado–Joseph disease (MJD), also known as Machado–Joseph Azorean disease, Machado's disease, Joseph's disease or spinocerebellar ataxia type 3 (SCA3), is a rare autosomal dominantly inherited neurodegenerative disease that causes progressive cerebellar ataxia, which results in a lack of muscle control and coordination of the upper and lower extremities. The symptoms are caused by a genetic mutation that results in an expansion of abnormal "CAG" trinucleotide repeats in the ATXN3 gene that results in an abnormal form of the protein ataxin which causes degeneration of cells in the hindbrain. Some symptoms, such as clumsiness and rigidity, make MJD commonly mistaken for drunkenness or Parkinson's disease.
