by José Machado · Lengua de Trapo · tapa blanda · ISBN 9788496080195
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Grillo is a novel by Spanish writer José Machado, published in 2003. The story follows an unsuccessful author who tries to regain control of his life with the help of a young neighbor and his best friend, after his girlfriend leaves him and he has not yet overcome the death of his parents and grandfather. Set in Madrid, the novel explores themes of loss, friendship, and the search for meaning in everyday life.
Machado–Joseph disease (MJD), also known as Machado–Joseph Azorean disease, Machado's disease, Joseph's disease or spinocerebellar ataxia type 3 (SCA3), is a rare autosomal dominantly inherited neurodegenerative disease that causes progressive cerebellar ataxia, which results in a lack of muscle control and coordination of the upper and lower extremities. The symptoms are caused by a genetic mutation that results in an expansion of abnormal "CAG" trinucleotide repeats in the ATXN3 gene that results in an abnormal form of the protein ataxin which causes degeneration of cells in the hindbrain. Some symptoms, such as clumsiness and rigidity, make MJD commonly mistaken for drunkenness or Parkinson's disease.
