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Lionel Henry Opie was a South African cardiologist. He was a professor of medicine at the University of Cape Town, where he conducted both experimental and clinical research on heart disease and cardiovascular physiology, metabolism, and pharmacology. He was the founding director of the university's Hatter Institute for Cardiovascular Research and the founding editor of the Journal of Molecular and Cellular Cardiology. He also served as president of the International Society for Heart Research.
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